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According to the reports from WHO (World Health Organization) (WHO and ITU Joint Report, 2014; WHO and ITU Joint Report, 2013), healthcare cost is becoming the unaffordable socio-economic problem in the world. Let us take cardiovascular disease (CVD) as an example. Only cardiovascular disease has contributed counting up to 29% of the total global deaths (Huang, 2014). Official statistics in (Huang, 2014) show that 230 million people in China - 1/5 of Chinese adults - suffer from cardiovascular diseases. On average, one patient dies from CVD every 10 seconds in China. In return, if the mortality rate from CVD could be reduced by 1% in next 3 decades, the reduction in total social cost would be about 10.7 trillion US dollars (68% of the 2010 Chinese fiscal year GDP). The cost of CVD has attracted attention from academic and industry communities in order to develop an early warning system for CVD monitoring (Global Survey Report, 2011; Estrin, 2010; Collins, 2012; Silva, 2013). The main causes of fatal cardiovascular disease include serious myocardial ischemia (acute myocardial infarction), heart failure, and malignant arrhythmia. As shown in (Bacquer, 1998; Falchuk, 2010; Usher, 2013), most of these symptoms can be predicted by observing certain specific manifestations of electrocardiogram (ECG) signals. If a system can detect such manifestations at an early phase, it can save valuable time for taking precautions against the cardiovascular disease (Caldeira, 2012; Zhang, 2012; Caldeira, 2013; Xie, 2014). To satisfy the requirement above, health conditions of CVD affected people must be collected and delivered to a professional healthcare center online, without unexpected disruption and distortion. Recent advances in information and communication technologies and engineering have provided an opportunity to accomplish this objective. Correspondingly, technology and engineering are becoming the indispensable ingredients for health information services today and future. Driven by this new trend, a new multidisciplinary area, Healthinfo Engineering, is born, which is changing health-care delivery today and at the core of responsive health systems in the future.