The international community is in the midst of a transition. As stated, this transition includes the infusion of anti-globalization ideologies into de-democratization (or authoritarian) politics, which is subsequently causing at the very least a trial separation amongst nation-states cooperatively handling global decision-making on shared issues of concern, to an all-out divorcing from the international alliances and organizations that characterize the globalized world order. The post-globalization, neo-nationalist, and mid-pandemic world order will (and is currently being) shaped by the turn away from multilateralism at a time in civilization’s history that seemingly calls for ‘all hands on deck’ to combat terrorism, get control of global warming and curb climate change, and ensure that no modern democratic nation-state is forced to ‘go it alone’ militarily or within the realm of foreign policy. The dangers of a return to a siloed hegemonic competition in terms of global cooperation are clear: this transition (which arguably began under Trump) marks a distinctive change in global mood and a homecoming for nationalist policies that tout things like America First, Britain First, or China First – rather than ‘we are in this together’. This chapter will explore the three most pressing issues in the 21st century, and those that are critical to have international input, buy-in, and cooperation in rectifying or balancing tensions.