This chapter explains the best practice in implementing e-business Technologies to achieve business cost reduction and business agility. Many companies started to realize that gaining competitive advantage is no longer feasible by only managing their own organizations; it also requires getting involved in the management of all upstream supply organizations as well as the downstream network. E-business technologies present huge opportunities that are already being tapped by several companies and supply chains. Although the benefits of implementing e-business technologies are clear, enterprises struggle in integrating e-business technologies into supply-chain operations. The author illustrates the strategic and operational impact of e-business technologies on supply chains and explains the performance benefits and challenges firms should expect in implementing these technologies. Also, the author provides the best-practice framework in leveraging e-business applications to support process improvements in order to eliminate non-value-added activities and provide real-time visibility and velocity for the supply chain. Finally, this chapter presents the future trends of using e-business in transformation programs.