Many Small and Medium Enterprises (SMEs) have been under pressures from large firms to implement Business-to-Business e-commerce (B2B e-commerce) information systems. However, these SMEs have faced various challenges to do so in the supply chain. This chapter explains the role of Taiwanese government in supporting SMEs in implementing e-commerce by analysing the interactions of government teams with current projects, and challenges of Taiwanese SMEs. Discussions and analyses focus on the government help in setting up infrastructure, B2B e-commerce implementation, and interfirm interactions among SMEs and larger firms. The Taiwanese government has been promoting its global logistic strategy for economic development which stresses supply chain integration by bridging information flows among overseas enterprises, domestic large firms, and local SMEs. Government projects related to this strategy are intended to anchor SMEs’ growing needs in linking B2B e-commerce with large firms. Our analyses and proposal dwell on how government can further bridge the gaps between the intrinsic barriers of SMEs and the interactions with larger firms in B2B e-commerce implementation.