The rapid evolution of information and communication technologies, the changing client’s demands, and market conditions impelled enterprises to adapt their way of undertaking business, from traditional practices to e-business, and to participate in new forms of collaboration, such as networked organizations. In this context, standards, frameworks, technologies, and infrastructures supporting collaborative business, in a networked environment, become key factors in achieving environments with a desired high level of collaboration and inter- and intra-organization business processes alignment. The aim of this chapter is to underline the main issues, trends, and opportunities related to business integration from a technological perspective, analyzing and discussing the most relevant (existing and still under development) business integration reference models, frameworks, standards, technologies, and supporting infrastructures, and to briefly present relevant research projects in the area of business networking. A special emphasis is made on frameworks such as ebXML and RosettaNet, and the importance of papiNet, BPLE4WS, and freebXML is underlined. Challenges regarding self-forming networked organizations are also advanced.