Security became a topic of research with the introduction of networked information systems, or networked IS, in the early eighties. In the mid-nineties the proliferation of the Internet in the business area exposed security as one of the key factors for successful online business, and the majority of effort to provide it was focused on technology. However, due to lessons learned during this period, the paradigms have since changed, with increasing emphasis on human factors. It is a fact that security of information systems is becoming part of the core processes in all e-business environments. While data is clearly one of the key assets and has to be protected accordingly, IS have to be highly integrated and open. Appropriate treatment of these issues is not a trivial task for managers of intelligent enterprises and requires new approaches, especially in light of new technologies.