This chapter discusses the challenges in constructing a culture-centric Web site. The Internet has expanded business opportunities into global marketplaces that were virtually unreachable in the past. With business Web sites reaching international audiences, cultural differences are an important issue in interface design. Global Web sites must be culture-centric, taking into account the attitude, technology, language, communication, sensibility, symbolism, and interface usability of targeted communities. Site design and development also should follow the Unicode standard for multilingual support with implementation done on UTF-8-enabled operating systems and applications. Globalization has led many people to become more sensitive to cultural diversity. The author hopes that understanding and awareness of international user needs, limitations, and expectations will lead to global Web sites with improved usability and sensitivity.