This chapter considers the perspective of small and medium-sized enterprises (SMEs) in supply chains. It starts with an overview of the important role of SMEs in national and world economies. Following this is an overview of supply chains, information and communication technologies, and e-business. Both opportunities and challenges for supply chains in general and SMEs in particular are considered, and conclusions drawn. The major contribution of the chapter is in providing an extensive overview of the literature as it relates to information and communication technologies, supply chain management, and SMEs, providing researchers and practitioners with a starting point to look for further information as needed.