The objective of this chapter is to evaluate the use of e-commerce across the value chains of several companies. In order to fulfil this objective, two different types of supply chain are analysed: the first type consists of buyer groups in the consumer goods sector; the second is dynamic networks in the manufacturing sector. Having identified what value activities are automated, the chapter examines the level of ICT and how value activity interactions between organisations are supported with e-commerce. Building on the analysis of e-commerce technology usage, the development of virtual structures is examined and the roles that SMEs can play in these. The chapter seeks to demonstrate that, with the introduction of e-commerce technologies in value activities across companies, the role of the current players is changing. Finally, the extent to which the traditional supply chain tiers change into more virtual value chain structures is evaluated.