Healthcare is one of the world’s most information-intensive industries. Every day, volumes of data are produced which, properly used, can improve clinical practice and outcomes, guide planning and resource allocation, and enhance accountability. Electronic health information is fundamental to better healthcare. There will be no significant increase in healthcare quality and efficiency without high quality, user-friendly health information compiled and delivered electronically. The growing use of information and communication technology (ICT) in the healthcare sector has introduced numerous opportunities and benefits to patients, providers and governments alike. Patients are being provided with tools to help them manage and monitor their healthcare, providers are able to seamlessly access up-to-date patient information, and governments are showing transparency to the public by reporting health data and information on their websites. There is mounting evidence that national, regional, and organizational e-health strategies are being developed and implemented worldwide. This chapter provides an overview of three different national e-health strategies, and identifies the lessons learned from the e-health strategies of Canada, England and Denmark.