As modern business activities become increasingly global, so too does information resource management (IRM). To manage information resources successfully in this global environment, one great challenge facing the management team is how to deal with national cultural differences. In this chapter, national cultural differences are discussed to indicate the substance of IRM challenges in a cross-cultural environment. Many recently published cases are studied to clarify management challenges of cross-cultural ISM. Primary management issues of mismatch between information presentation and information procurement are analyzed in particular detail. Further, management solutions oriented for IRM in a cross-cultural environment are explored. Due to the lack of similar research topics, this study could supply a gap for cross-cultural IRM. The contribution of this chapter will be twofold: one is to set up a sound management mechanism for cross-cultural IRM; the other is to create sharable information resources in a cross-cultural environment.