Until recent years, the end user computing ergonomic focus has primarily been on stationary computer use. A new trend for the end user is mobile computing. An increasing number of end users are working outside of the traditional office. Mobile computing devices allow for these workers to perform job functions while in the field, at home, or while traveling. The organizational and end user benefits abound for the use of such enabling technology. However, the mobile computing environment introduces a new area of ergonomic concerns. Are businesses and end users monitoring the use of these devices from an ergonomic perspective? The good news is the outcome can be influenced and/or determined with intentional efforts on the part of both end users and managers. This paper includes an in depth review of the current and emerging issues, especially the mobile end user environment, that is important to the end user, manager, and organization as a whole. It also provides end user ergonomic suggestions and resources and addresses the management challenges rising from ergonomic issues.