The 21st century continues to witness the transformation of organizational systems globally through the deployment of information and communication technologies (ICT). The emerging future is witnessing the convergence of artificial intelligence, biotechnology, nomadic information systems, and nano-technology. This promises to further compel inter-organizational and inter-sectorial interactive transformations. The health care sector is no exception to the interorganizational dynamic imperatives driven with ICT innovative advances. This article proposes a conceptual model of symbiotic e-health networks in a meta-cultural domain that goes beyond the realm of extant literature on dyadic relationships. The model dimensions are posited on a key informant approach and content analysis of the strategic perceptions of international ICT and health care executives interacting through dyadic partnerships. The findings and implications of the study for the model and further information management research are underscored. The underlying meta-cultural frame is characterized by public governance values and the article explores its perceived role in sustaining symbiotic e-health networks in Canada and Sweden.