The chapter describes the Tecnológico de Monterrey implementation of an original ePortfolio model at the Mexico City campus. This model is grounded on student reflection in three broad areas of students’ lives designed by Jesus Meza, PhD. The implementation was launched in August 2002, with 60 students studying two different majors. By January 2005, the number of student portfolios had grown to 5,000, covering 18 different majors. According to the mission of the Tecnológico de Monterrey for the year 2015, the authors consider that the ePortfolio model will evolve into a comprehensive communication tool reflecting the personal, academic, and professional achievements of the community at the Tecnológico de Monterrey.