This chapter explores information technology (IT) issues in regard to an organization’s transition towards globalization. The challenges of IT dealing with transforming enterprises to globalized organizations require the identification, consolidation, and resolution of issues to support the organizations towards globalization. The chapter begins with identifying and classifying four major IT transition issues: global IT infrastructure, global business applications, global telecommunication network, and data/information systems improvement. It is then followed by detailed discussion of each issue with regards to its importance and relevance in global transformation. The chapter concludes by indicating a future research direction to incorporate organizational scopes (inter-organizational and intra-organizational) in the global IT transition framework.