With increasing ability to interact globally through the electronic medium, businesses are able to tap into newer business opportunities externally as well as capitalize internally on pools of resources and talents spread across the globe. However one of the major hindrances to the utilisation of these opportunities and talents through global alliances is cross-cultural issues. While technology renders the geographical boundaries redundant, it aggrandizes the chasms in socio-cultural value systems of physically disparate alliance partners. This chapter discusses the gamut of global e-business alliance: the primary reasons for their needs, their socio-cultural perspective, and the various factors that influence such alliances. Finally the corresponding mitigating approaches to those negatively influencing factors are suggested.