This project was designed to identify the legal implications associated with the management of sickle cell in newborns and to discuss the socio-cultural implications in the management of sickle cell in newborns. In assessing the ethical components of neonatal screening for sickle cell disease one must consider the implications for screening at-risk subject bearing in mind those there relevant therapeutic interventions for the management of the disease. Besides, conscientious efforts are needed to determine the ethical and the financial implications of treating newborn with sickle cell anemia as a public health priority among physicians, administrators and health educators in Sub-Saharan African (SSA) nations.