This chapter explores privacy and security issues in health care. It describes the difference between privacy and security in the context of health care, identifies sources of concern for individuals who use information technologies for health-related purposes, and presents technology-based solutions for privacy and security in health care networks. The purpose of the chapter is to provide an investigation of the sources of concern for regulations and technologies in the health care industry. The discussion is based on the Health Insurance Portability and Accountability Act (HIPAA) and its eight guiding principles. The chapter explores the implications of legal and regulatory environments driving HIPAA regulations, the need for privacy and security in health care networks, and information technologies used in the health care industry. Related ethical issues, current technologies for providing secure solutions that comply with the regulations, and products emerging in the market are also examined.