Developing human-engineered systems is considered as a challenge that addresses a wide area of expertise; computer scientists as well as social scientists. These experts have to work together closely in teams in order to build intelligent systems to support agile software development. The methodology developed in the RISE project enables and supports the design of human-centered knowledge-sharing platforms, such as Wikis based on standards in the field of education science. The project “RISE” (Reuse In Software Engineering) is part of the research program “Software Engineering 2006” funded by the German Federal Ministry for Education and Research (BMBF). The goal was to improve the reuse of artifacts in software engineering, and brought together researchers from education science (The Department of Educational Sciences and Professional Development at the Technical University of Kaiserslautern) and computer science (Fraunhofer Institute for Experimental Software Engineering (IESE) and the German Research Center for Artificial Intelligence (DFKI)) with industrial partners (Empolis GmbH and brainbot technologies AG). This chapter gives an overview about the human-centered design of Wiki-based knowledge and learning management systems in software engineering projects, and raises several requirements one should keep in mind when building human-centered systems to support knowledge and learning management.