This chapter addresses the lack of attention paid to what is commonly referred to as an organization’s greatest asset, its people, in an increasingly Internet-connected business environment. The literature suggests that Internet usage is growing exponentially and is likely to have a huge impact on the way businesses are run and how they interact with their customers, their suppliers and their business partners. While there has been a range of research done on the profile of online users, types of sites, number of hits and income generated from Internet sales, there is a distinct lack of research about the impact of the Internet on the functioning of organizations and the impact on their systems and processes. Lack of in-depth information about the effect an integrated Internet presence has on an organization has a number of important implications. We are not yet fully aware of the best processes and practices to implement to ensure effective and efficient online organizations. This chapter has relevance for business operators and academics who wish to understand how business principles transfer into an online environment, and what new strategies and techniques are required to realize the potential opportunities and benefits of this medium. Special emphasis is placed on the human factors and communication issues involved.