This chapter attempts to enhance the understanding and knowledge of Information and Communication Technologies (ICTs) in relation to the Tanzania National ICT Policy as a case study. The authors extensively explore these pervading technologies as they impact on the education, commerce, social, cultural, and economic life of the poor Tanzanian people. The chapter looks at how Tanzania is coping with the issue of poverty eradication as one of the eight UN Millennium Development Goals (MDGs). It addresses the issue of digital divide and the role that ICTs can play in poverty reduction. Tanzania’s efforts in embracing ICTs and the challenges facing the country in its efforts are also addressed. Overall, the chapter demonstrates that ICTs are a set of tools for knowledge sharing, which is a powerful means for poverty reduction. Furthermore, it is advisable to focus on information literacy rather than just focusing on computer literacy.