This chapter investigates the role of information and knowledge management in innovation of complex technologies. A conceptual framework for three patterns of technological innovation (normal, transitional, and transformational) is presented, and the process of information and knowledge management in accessing and using knowledge is analyzed. Particularly, emphasis is put on the cultural impact on the information and knowledge management processes. Five case studies of evolving technologies carried out in the United States, Japan, Germany, India, and China are used to elaborate the conceptual framework and key points presented in this chapter. Lessons for managers and public policymakers concerned with facilitating the innovation of technologies are discussed.