Recent rise in the level of comfort and demand to access various types of information using mobile devices can be attributed to the advancements in wireless as well as Internet technologies. This demand leads us to the new era of mobile computing. Location-based services (LBS) are engendering new passion in mobile services utilizing users’ location information. Such spatio-temporal information processing entails the need for a dynamic middleware that accurately identifies changing user location and attaches dependent content in real-time without putting extra burden on users. Our work focuses on creating a distributed infrastructure suitable to support such scalable content dissemination. As a result this chapter offers a conceptual framework, location-aware intelligent agent system (LIA) in integration with publish/subscribe middleware to comprehensively address dynamic content dissemination and related issues. We discuss the operational form of our framework in terms of PUSH and PULL strategies.