This chapter presents a framework to integrate effectively different information technologies in order to raise the intelligence and manage the knowledge of a metabusiness, an innovative business model. The concept of intelligence in a metabusiness is analyzed and the information technologies needed to create this new business environment are presented, as well as an integrated model based on a technology-service-process-production taxonomy. A case study addressing a major engineering company in Brazil, now playing the role of an integrator within a metabusiness, is presented in order to validate the proposed model. The main obstacles and hurdles to accomplish an intelligent metabusiness are presented as well as the solutions to overcome them. Future trends and some conclusions in this realm are presented, mainly the ones regarding how to leverage the Human and Innovation Capital in a metabusiness.