This chapter proposes a conceptual framework of e-business strategy. It argues that such a framework must be holistic, dynamic, and dialectical. This framework will assist both researchers and practitioners regarding the key issues of e-business strategy. Further, a case study of Haier from China reveals that all firms need to learn how to design effective e-business strategies that should be built on a sound organizational form or business model. The case of Haier also suggests that the local firms from the developing countries need to be creative in formulating e-business strategies in order to operate effectively in the underdeveloped e-business environment. Strategic alliance is especially critical for the local firms with regard to their e-business success.