This chapter introduces a business integration framework suitable for knowledge management in research and development (R&D) organizations in the high-technology sector. The knowledge management platform design is based on the latest technological trends and standards. Two main constituents of the proposed system are: the document warehouse layer, based on data warehousing methodology; and the semantic layer, based on the latest semantic technologies ontologies and Web services. The initial results of introducing such a platform at the Mihajlo Pupin Institute (MPI) in accordance with the adopted ISO 9001 Quality Assurance standard are presented and discussed. The implementation of this integrated system is a large, multifaceted project carried on by turns in a bottom-up and top-down manner. Its use at MPI will facilitate reusability of knowledge items, and enhance creativity and innovation.