This chapter explores the use of knowledge management with emergency information systems. Two knowledge management systems that were utilized during Hurricane Katrina response are described and analyzed. The systems specified were developed by both federal agencies as well as grass root efforts without the support or mandate of government programs. These programs, although developed independently, were able to share data and interact in life saving capacities, transcending traditional geo-political boundaries. We conclude that emergency information systems are enhanced by incorporating knowledge management tools and concepts.