In today’s competitive business environment, increasingly large numbers of organisations use virtual distributed teams in their operations. This chapter provides a basis for discussion and analysis of knowledge sharing in culturally diverse networked organisations. Examining the different cultural values and perceptions related to knowledge sharing, we aim at making the human and cultural dynamics that bear on knowledge sharing and knowledge management success more explicit. The objectives are to foster an effective knowledge-sharing culture within virtual distributed teams. The chapter provides mechanisms for understanding the potential for conflict, for knowledge sharing, and building of trust among culturally diverse team members. Guidelines for successful knowledge sharing in the global environment are developed providing indications of the expected benefits for the organisation and the individuals involved. An outline of future trends and further work complete the chapter.