This chapter introduces a life-cycle cost (LCC) analysis of bridge structures considering seismic risk. Recently, LCC has been paid attention as a possible and promising method to achieve a rational maintenance program. In general, LCC consists of initial cost, maintenance cost, and renewal cost. However, when considering LCC in the region that often suffers from natural hazards such as typhoons and earthquakes, it is necessary to account for the effects of such natural hazards. Using the probability of damage occurrence, LCC can be calculated for the bridge structures with earthquake excitations. The LCC analysis method proposed in this chapter can be applied to optimal maintenance planning by using genetic algorithms and can be extended to the life-cycle cost analysis of road network.