Digital inclusion and Web accessibility are integral parts of modern culture and, as such, have implications for social accountability. The World Wide Web Consortium (W3C) has suggested standards and guidelines regarding the inclusion of people with special needs, with an emphasis on higher accessibility and adaptability as the main goal of Web design. The user interface is the place where users can interact with the information by using their minds. Users with special needs can acquire information by using a human centered user interface. This article highlights the need to investigate the relationship between cognition and user interface.