In this chapter, we explore the impact of modern maintenance management on the global organizational efficiency of an intelligent enterprise. In order to do so, we first define the concept of maintenance management, its scope, and complexity. We also define the company’s organizational efficiency as a suitable balance of each of these competencies: product, process and relationship. The chapter describes how this function may impact a company’s competencies in product and processes. To be effective, maintenance function requires the proper development of relationship competencies with technological partners, suppliers and the end customers. Therefore, this chapter proposes a comprehensive maintenance management framework that integrates various existing approaches to maintenance management. We also discuss useful practices to reach the competencies needed to be effective in the maintenance function of intelligent enterprises.