Online instruction in a nursing program strikes fear into the most dedicated and compassionate nursing instructor. Concerns range from unfamiliarity with online pedagogy to the potential for decreased student connectedness. Being unfamiliar with the online format can be overcome through a series of self-training, taking courses online, and dedication to the process. Student connectedness is basic to the caring and compassionate professions, and some assume the online format will create an atmosphere of disconnectedness and isolation. To combat this disconnectedness and isolation, an attitude of caring and an atmosphere of mentoring are required in the online classroom. This article considers the basics of both the concepts of caring and online instruction.