Over the last couple of years, e-procurement has received tremendous attention from researchers and practitioners alike. However, research on e-procurement is still scarce and scattered. This chapter looks into prior research on inter-organizational information systems (IOIS), electronic data interchange (EDI), channel management, and procurement to develop a research framework and identify research issues in e-procurement. It is argued that supply market characteristics and product characteristics can explain the emergence of various e-procurement systems. Further, these e-procurement systems have different impacts on inter-organizational relationships and value generated from e-procurement. However, these impacts are moderated by adoption and implementation risks. Though this model provides us with a holistic view to e-procurement, it is not yet empirically validated, owing to low e-procurement penetration.