This chapter will exhibit the experience of applying project-based learning in different subject matter, identifying and comprehending the efficiency of this teaching methodology from an analysis of the activities undertaken. The subjects focused on were transport phenomena and unit operations in chemical processes. The methodology of project-based learning is to associate concepts acquired during classes and integrate them with other subjects in order to integrate the parts into the whole. It develops a variety of skills in addition to technical ones, such as cooperation, communication, involvement, knowledge construction, decision making and problem solving. All these skills being supported by the use of distance education tools. The creation of the subjects in a virtual environment sustains student materials previously required for project development. It also monitors of student activity (access by frequency statistics), and facilitates communication. The motivation and interactivity aspects have been shown to be positive with students and professors systematically involved in the constructive evolution of both individual and group knowledge.