The present case study explains the process of creation of Remote Internet-Based Supervision Systems, S.L. (RISS), a spin-off emerging from the University of Figueres, Spain. It describes all phases, from formation to the present day, and the problems and challenges faced by the entrepreneurial team composed of academics and industry professionals. Starting in a lab shared by two computer engineers finishing their PhDs, their friendship later converted into a science-based new venture. After having developed products and survived financial difficulty, the company stood at the threshold of a stage of growth and a decision regarding the commercial strategy had to be taken. But some problems have arisen between the academic entrepreneurs and the industrial partner regarding commercial strategy.