One of the key factors that distinguishes enterprises of the 21st Century is the emphasis on knowledge and information. Knowledge management is an important means by which organizations can better manage information, and more importantly, knowledge. Unlike other techniques, knowledge management is not always easy to define, because it encompasses a range of concepts, management tasks, technologies, and practices, all of which come under the umbrella of the knowledge management. This chapter deals with two aspects of knowledge management systems: (a) why KM systems are needed, and (b) how to get started on designing and rolling out a new or improved KM system. The inferences are drawn from the direct experiences the authors have had during their academic and consulting activities in many health sector organizations.