Stochastic Simulations in Systems BiologyMarc Hafner (Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland) and Heinz Koeppl (Swiss Federal Institute of Technology Zurich (ETHZ), Switzerland)
Copyright © 2012. 20 pages.
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DOI: 10.4018/978-1-61350-116-0.ch012, ISBN13: 9781613501160, ISBN10: 1613501161, EISBN13: 9781613501177 Sample PDFCite Chapter
MLA
Hafner, Marc and Heinz Koeppl. "Stochastic Simulations in Systems Biology." Handbook of Research on Computational Science and Engineering: Theory and Practice. IGI Global, 2012. 267-286. Web. 23 May. 2012. doi:10.4018/978-1-61350-116-0.ch012
APA
Hafner, M., & Koeppl, H. (2012). Stochastic Simulations in Systems Biology. In J. Leng, & W. Sharrock (Eds.), Handbook of Research on Computational Science and Engineering: Theory and Practice (pp. 267-286). Hershey, PA: Engineering Science Reference. doi:10.4018/978-1-61350-116-0.ch012
Chicago
Hafner, Marc and Heinz Koeppl. "Stochastic Simulations in Systems Biology." In Handbook of Research on Computational Science and Engineering: Theory and Practice, ed. J. Leng and Wes Sharrock, 267-286 (2012), accessed May 23, 2012. doi:10.4018/978-1-61350-116-0.ch012
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 | | TopAbstractWith the advances in measurement technology for molecular biology, predictive mathematical models of cellular processes come in reach. A large fraction of such models addresses the kinetics of interaction between biomolecules such as proteins, transcription factors, genes, and messenger RNA. In contrast to classical chemical kinetics – utilizing the reaction-rate equation – the small volume of cellular compartments requires accounting for the stochasticity of chemical kinetics. In this chapter, we discuss methods to generate sample paths of this underlying stochastic process for situations where the well-stirredness or fast-diffusion assumption holds true. We introduce various approximations to exact simulation algorithms that are more efficient in terms of computational complexity. Moreover, we discuss algorithms that account for the multi-scale nature of cellular reaction events. TopComplete Chapter List|
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