This chapter reviews the benefits and challenges of five approaches for integrating technology and teaching. Three of the models involve distance learning, while the two others utilize technology as a teaching aid. The first model is a lecture-based course also available through a Web site. The second is a fully online asynchronous course. The third is synchronous distance learning. The fourth combines a virtual laboratory and visualization with regular teaching, and the fifth fuses technology with different teaching methods. The pedagogical and operational aspects of the five approaches are discussed. The main pedagogical aspects discussed are: applying active and interactive learning principles, using multimedia, organizing the course and its lessons, and providing immediate feedback to students about their progress. By comparing the advantages and challenges the different models offer, teachers in K-12 will be able to match the appropriate model and its teaching strategy to their learning goals.