Enterprise resource planning (ERP) systems have become indispensable software systems for many corporations worldwide. As more and more companies implement ERP to sup-port daily business transactions, the need for ERP trained employees are increasing as well. Industry demand has prompted many universities to consider incorporating ERP into their curricula. Information systems curriculum in many universities have started offering courses that include ERP education; however, most universities have faced multi-faceted challenges related to lab setup, training, software support, and curriculum design. In this chapter, a guideline for development and teaching an ERP based course with MS Great Plains™ is provided. Teaching approach is discussed and an ERP based business curriculum is proposed. Effectiveness of the curriculum design in the classroom is analyzed based on a single semester trial of the course in two classrooms.