Because of the rapid growth of health evidence and knowledge generated through research, and growing complexity of the health system, clinical care gaps increasingly widen where best practices based on latest evidence are not routinely integrated into everyday health service delivery. Therefore, there is a strong need to inculcate knowledge translation strategies into our health system so as to promote seamless incorporation of new knowledge into routine service delivery and education to promote positive change in individuals and the health system towards eliminating the clinical care gaps. E-health, the use of information and communication technologies (ICT) in health which encompasses telehealth, health informatics, and e-learning, can play a prominently supportive role. This chapter examines the opportunities and challenges of technology enabled knowledge translation (TEKT) using ICT to accelerate knowledge translation in today’s health system with two case studies for illustration. Future TEKT research and evaluation directions are also articulated.