A system of innovation (SI) is a new approach for the study of innovations as an endogenous part of the economy. An SI can be defined as encompassing all the important factors that influence the development, diffusion, and use of innovations as well as the relations between these factors. For example, the SI approach is also used as a framework for designing innovation policy at the national level in some EU (European Union) member countries such as Finland and Ireland. It is simply at the center of modern thinking about innovation and its relation to economic growth, competitiveness, and employment. In this chapter, the adaptation of this framework for telemedicine applications is simply presented.