Remote, collaborative work practices are increasingly common in a globalised society. Simulating these environments in a pedagogical setting allows students to engage in cross-cultural exchanges encountered in the profession. However, identifying the pedagogical benefits of students collaborating remotely on a single project presents numerous challenges. Activity Theory (AT) provides a means for monitoring and making sense of their activities as individuals and as a collective. AT assists in researching the personal and social construction of students’ intersubjective cognitive representations of their own learning activities. Moreover, AT makes the socially constructed cultural scripts captured in their cross-cultural exchanges analysable. Students’ reflection on these scripts and their roles in them helps them better understand the heterogeneity of the cultures encountered. In this chapter Engestrom’s (1999) simple AT triangular relationship of activity, action and operation is used to analyze and provide insights into how students cooperate with each other across different cultures in a 3D collaborative virtual environment.