How reality or the world with its parts and levels might be truly symbolized and represented by emerging semantic technology and knowledge systems appears the most challenging topic in the field of top ontology and ontology engineering. Along with causality, knowing the relationship of meaning makes all the difference in true representation of the real world features, in understanding (sensing, reading, or resolving) the real meaning values of world knowledge representation and reasoning. A formal account of meaning (or significance) is becoming a decisive issue in the whole matter of the Semantic Web promising machine-based processing by means of advanced information technologies. For without understanding the nature of meaning, its critical dimensions, mechanisms, and algorithms of representation in computable forms, the whole enterprise of semantic technology is an otiose undertaking and expensive academic mystification. As far as computing ontology is viewed as a semantic model where the relationships among resources are to be identified, differentiated, or processed by automated tools [SICoP, 2005], the above meaningful topics presuppose creating the standard ontology framework. As far as the emerging Semantic Web is the universal medium for the exchange of information across users, systems, applications, and networks, the unified frame ontology is the universal semantic platform for a uniform organization of all human knowledge.