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What is DNA Microarray (microarray, array, DNA chip)

Handbook of Research on Systems Biology Applications in Medicine
A microarray is a collection of microscopic DNA spots, commonly representing sequence extracts of single genes, arrayed on a solid surface by covalent attachment to a chemical matrix. DNA arrays are commonly used for gene expression experiments.
Published in Chapter:
Approaching Type 2 Diabetes Mellitus by Systems Biology
Axel Rasche (Max-Planck-Institute for Molecular Genetics, Germany)
Copyright: © 2009 |Pages: 16
DOI: 10.4018/978-1-60566-076-9.ch022
Abstract
We acquired new computational and experimental prospects to seek insight and cure for millions of afflicted persons with an ancient malady. Type 2 diabetes mellitus (T2DM) is a complex disease with a network of interactions among several tissues and a multifactorial pathogenesis. Research conducted in human and multiple animal models has strongly focused on genetics so far. High-throughput experimentation technics like microarrays provide new tools at hand to amend current knowledge. By integrating those results the aim is to develop a systems biology model assisting the diagnosis and treatment. Beside experimentation techniques and platforms or rather general concepts for a new term in biology and medicine this chapter joins the conceptions with a rather actual medical challenge. It outlines current results and envisions a possible alley to the comprehension of T2DM.
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