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What is Endogenous Skin Aging

Chapter 19
Handbook of Research on Systems Biology Applications in Medicine
Endogenous aging, otherwise called intrinsic or chronological aging, is influenced by genetics, hormonal changes and metabolic processes, which appear at advanced age. Endogenous skin aging can be viewed on non UV-exposed areas of the body and can be considered as model of the aging process taking place in internal organs.
Published in Chapter:
The Sebaceous Gland: A Model of Hormonal Aging
Evgenia Makrantonaki (Dessau Medical Center, Germany and Charité Universitaetsmedizin Berlin, Germany)
Copyright: © 2009 |Pages: 7
DOI: 10.4018/978-1-60566-076-9.ch019
Abstract
This chapter introduces an in vitro model as a means of studying human hormonal aging. For this purpose, human sebaceous gland cells were maintained under a hormone-substituted environment. This environment consisted of growth factors and sex steroids in concentrations corresponding to those circulating in young and postmenopausal women. The authors suggest that hormone decline, occurring with age, may play a significant role not only in the maintenance of skin homeostasis but also in the initiation of aging. Furthermore, skin, the largest organ of the body, offers an alternative approach to understanding the molecular mechanisms underlining the aging process.
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