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What is Likelihood Function

Chapter 29
Handbook of Research on Systems Biology Applications in Medicine
It is the probability of the occurrence of a sample configuration. The conditional probability distribution of a random variable given the parameters of the distribution has to be known. L ( q | X = x ) = P ( X = x | q ) is a likelihood function, where X is a random variable, x is the observed value of X , and q is a parameter.
Published in Chapter:
Methods for Reverse Engineering of Gene Regulatory Networks
Hendrik Hache (Max Planck Institute for Molecular Genetics, Germany)
Copyright: © 2009 |Pages: 19
DOI: 10.4018/978-1-60566-076-9.ch029
Abstract
In this chapter, different methods and applications for reverse engineering of gene regulatory networks that have been developed in recent years are discussed and compared. Inferring gene networks from different kinds of experimental data are a challenging task that emerged, especially with the development of high throughput technologies. Various computational methods based on diverse principles were introduced to identify new regulations among genes. Mathematical aspects of the models are highlighted, and applications for reverse engineering are mentioned.
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