Search the World's Largest Database of Information Science & Technology Terms & Definitions
InfInfoScipedia LogoScipedia
A Free Service of IGI Global Publishing House
Below please find a list of definitions for the term that
you selected from multiple scholarly research resources.

What is Locally Weighted Normalization of a Scatter Plot (LOESS:LOWESS)

Encyclopedia of Healthcare Information Systems
LOESS seeks to find a low order polynomial that best describes the overall variation in a scatter plot. This is used to normalize for the nonlinearities found in two state experiments.
Published in Chapter:
Assessing the Information Content of Microarray Time Series
E. Yang (Rutgers University, USA) and I. P. Androulakis (Rutgers University, USA)
Copyright: © 2008 |Pages: 8
DOI: 10.4018/978-1-59904-889-5.ch017
Abstract
While the rise of microarrays has heralded a new era in molecular biology with its ability to measure the expression level of thousands of genes at once, the usefulness of microarrays is exigent upon the ability to obtain accurate gene expression data for the individual genes (Bowtell, 1999; Brown & Botstein, 1999; Cheung, Morley, Aguilar, Massimi, Kucherlapati, & Childs, 1999). However, there has been significant criticism as to how meaningful the information derived via microarrays is. In cases where one has attempted to find genes that correlated to types of cancer or survival rate, it was found that different analysis techniques would often times yield radically different set of genes, calling into question the validity of the overall experiment itself (Dupuy & Simon, 2007). It is our contention that part of the problem associated with microarrays is that there does not exist a coherent method for dealing with data quality, and if a coherent method for dealing with data quality existed, many of the criticisms of microarrays could be addressed.
Full Text Chapter Download: US $37.50 Add to Cart
eContent Pro Discount Banner
InfoSci OnDemandECP Editorial ServicesAGOSR