What is Positive and Negative Feedback

In this chapter some model development concepts can be used for the mathematical modeling in physiology as well as a graph theoretical approach for a decomposition technique in order to simplify parameter estimation are presented. This is based on the human menstrual cycle. First some modeling fundamentals are introduced that are applied to the model development of the human menstrual cycle. Then it is shown how a complex mathematical model can be handled if a large number of parameters are used where the parameter values are not known for the most part. A method is presented to divide the model into smaller, disjoint model parts. At the same time, it is shown how this technique works in the case of the human menstrual cycle. The principles for model development and decomposition can be used for other physiological models as well.