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What is Systems Biology

Chapter 5
Handbook of Research on Systems Biology Applications in Medicine
The study of an organism, viewed as an interacting network of genes, proteins, and biochemical reactions which give rise to life. Instead of analyzing individual aspects of the organism, systems biologists focus on all the components and the interactions among them. Systems Biology is the discipline that specifically addresses the fundamental properties of biological complexity.
Published in Chapter:
Synthetic Biology as a Proof of Systems Biology
Andrew Kuznetsov (Freiburg University, Germany)
Copyright: © 2009 |Pages: 19
DOI: 10.4018/978-1-60566-076-9.ch005
Abstract
Biologists have used a reductionist approach to investigate the essence of life. In the last years, scientific disciplines have merged with the aim of studying life on a global scale in terms of molecules and their interactions. Based on high-throughput measurements, Systems Biology adopts mathematical modeling and computational simulation to reconstruct natural biological systems. Synthetic Biology seeks to engineer artificial biological systems starting from standard molecular compounds coding in DNA. Can Systems and Synthetic Biology be combined with the idea of creating a new science—‘SYS Biology’ that will not demarcate natural and artificial realities? What will this approach bring to medicine?
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Chapter 37
Bioinformatics
The study of networks of interactions among the components of a biological system, emphasising a synthetic, non-reductionist approach and emergent properties.
Published in Chapter: Bioinformatics; From: Encyclopedia of Information Science and Technology, Fourth Edition
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Chapter 6
Modeling the Microbial Cells for Biotechnological Applications
It is a comprehensive quantitive analysis of the behavior and interaction of biological components including molecules, cells, organs, and cells.
Published in Chapter: Modeling the Microbial Cells for Biotechnological Applications; From: Applications of Synthetic Biology in Health, Energy, and Environment
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Chapter 44
Structural Equation Modeling for Systems Biology
A biology-based inter-disciplinary field of study that focuses on complex interactions within biological systems with holistic perspective.
Published in Chapter: Structural Equation Modeling for Systems Biology; From: Encyclopedia of Information Science and Technology, Third Edition
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Chapter 20
Systems Biology Applied to Cancer Research
A field which studies complex biological systems at different levels to decipher the interactions of its key components and provide a mathematical model integrating this heterogeneous information.
Published in Chapter: Systems Biology Applied to Cancer Research; From: Handbook of Research on Systems Biology Applications in Medicine
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Chapter 42
Text Mining in Bioinformatics: Research and Application
The study of the interactions between the components of biological systems, and how these interactions give rise to the function and behavior of that system.
Published in Chapter: Text Mining in Bioinformatics: Research and Application; From: Handbook of Research on Text and Web Mining Technologies
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Chapter 122
Best Practices of Feature Selection in Multi-Omics Data
It is the computational and mathematical analysis and modeling of complex biological systems. It is an approach in biomedical research to understand the larger picture, be it at the level of the organism, tissue, or cell, by putting its pieces together.
Published in Chapter: Best Practices of Feature Selection in Multi-Omics Data; From: Encyclopedia of Data Science and Machine Learning
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Chapter 38
Bioinformatics
The study of networks of interactions among the components of a biological system, emphasising a synthetic, non-reductionist approach and emergent properties.
Published in Chapter: Bioinformatics; From: Encyclopedia of Information Science and Technology, Third Edition
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Chapter 23
A Framework for Semantic Grid in E-Science
The application of the systems and control theory to complex Biological problems.
Published in Chapter: A Framework for Semantic Grid in E-Science; From: Handbook of Research on Grid Technologies and Utility Computing: Concepts for Managing Large-Scale Applications
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Chapter 26
Overview of Cellular Computing-Basic Principles and Applications
A biology centered interdisciplinary field of study that focuses on systemic study (holistic approach) of complex interactions of biological systems. With insights gained from experimental biology, systems biology incorporates computational and mathematical (with some statistical inputs) modeling and simulation techniques and tools for a comprehensive and quantitative analysis of biological interactions.
Published in Chapter: Overview of Cellular Computing-Basic Principles and Applications; From: Handbook of Research on Natural Computing for Optimization Problems
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