|Total results: 416||
|BMP Signaling in Regenerative Medicine
Julia Zimmer, Elisa Degenkolbe, Britt Wildemann, Petra Seemann.
More than 40 years after the discovery of Bone Morphogenetic Proteins (BMPs) as bone inducers, a whole protein family of growth factors connected to a wide variety of functions in embryonic development, homeostasis, and regeneration has been characterized. Today, BMP2 and BMP7 are already used in the...
Modeling Colorectal Cancer: A Stability Analysis Approach
Svetoslav Nikolov, Mukhtar Ullah, Momchil Nenov, Julio Vera Gonzalez, Peter Raasch, Olaf Wolkenhauer.
Mathematical modeling is increasingly used to improve our understanding of colorectal cancer. In the first part of this chapter, the authors give a review of systems biology approaches to investigate colorectal cancer. In the second part, the mathematical model proposed by Johnston et al. (2007) is...
Immunogenicity of Stem Cells
Franz Ricklefs, Sonja Schrepfer.
Current medical research is focused on two particular types of stem cells, adult stem cells and embryonic stem cells. Both cell types demonstrate a tremendous potential as the source for regenerative medicine due to their paracrine and pluripotency effects, respectively. Therefore, stem cells are...
Regulatory T Cell-Based Immunotherapy: Prospects of Antigen-Specific Tolerance Induction
Sonja Schallenberg, Cathleen Petzold, Julia Riewaldt, Karsten Kretschmer.
CD4+CD25+ regulatory T (Treg) cells expressing the forkhead box transcription factor Foxp3 have a vital function in the maintenance of immune homeostasis and the prevention of fatal multi-organ autoimmunity throughout life. In the last decade, Foxp3+ Treg cells have raised the hope for novel cell-based...
Regeneration of Articular Cartilage: Opportunities, Challenges, and Perspectives
This chapter reviews the structure and function of articular cartilage and the pathogenesis of Osteoarthritis (OA) before exploring the challenges associated with cartilage repair and regeneration. Surgical techniques for cartilage repair are critically reviewed and special emphasis is placed upon...
Generation of Scaffold Free 3-D Cartilage-Like Microtissues from Human Chondrocytes
Frank Martin, Mario Lehmann, Ursula Anderer.
Since our society is characterized by an increasing age of its people on the one hand and a high number of persons dealing with sports on the other hand, the number of patients suffering from traumatic defects or osteoarthritis is growing. In combination with the articular cartilage specific limited...
The Hidden Markov Brains
Tuan D. Pham.
This chapter presents Hidden Markov models (HMM) of the brain on Magnetic Resonance Imaging (MRI) for the inference of white matter hyperintensities and brain age prediction to study the bidirectional vascular depression hypothesis in the elderly and neurodegenerative diseases, respectively. Rating and...
Heart Valve Diseases in the Elderly: Current Treatments and Future Directions
Yos Morsi, Zhang Li, Sheng Wang.
This chapter gives an overview of heart valve diseases, their diagnostics techniques, and current and future treatments with particular emphasis on the elder generation. It starts with a brief presentation of anatomy of the heart and its valves and the effect of aging on the function of the heart....
Tactile Resonance Sensors for Detection and Diagnosis of Age-Related Diseases
Olof A. Lindahl, Anders Eklund, Per Hallberg.
The chapter involves the description and the application of a new sensor technology called tactile resonance sensors for diagnoses of the age-related diseases glaucoma and prostate cancer. Tactile resonance sensors in general are used for measuring the parameters of a contact between sensor and object...
Dental Tissue Engineering Research and Translational Approaches towards Clinical Application
Athina Bakopoulou, Gabriele Leyhausen, Werner Geurtsen, Petros Koidis.
Stem cell-based dental tissue regeneration is a new and exciting field that has the potential to transform the way that we practice dentistry. It is, however, imperative its clinical application is supported by solid basic and translational research. In this way, the full extent of the potential risks...
GIS Application of Healthcare Data for Advancing Epidemiological Studies
Joseph M. Woodside, Iftikhar U. Sikder.
Healthcare practices increasingly rely on advanced technologies to improve analysis capabilities for decision making. In particular, spatial epidemiological approach to healthcare studies provides significant insight in evaluating health intervention and decisions through Geographic Information Systems...
Evidence-Based Practice in Nursing Informatics: Concepts and Applications
Andrew Cashin, Robyn Cook.
Because of the constant advances and dynamics within the nascent field of nursing informatics, many nurses struggle in practice as they continue to try and apply habitual communication practices in the new environment without any critical reflection on, and adaptation of, those practices.Evidence-Based...
Clinical Technologies: Concepts, Methodologies, Tools and Applications
Information Resources Management Association.
Modern technological advances in medicine are not restricted to treatments, but rather have revolutionized the entire application of healthcare from finding a doctor to executing a treatment.Clinical Technologies: Concepts, Methodologies, Tools and Applications provides an exhaustive chronicling of...
Techniques for Medical Image Segmentation: Review of the Most Popular Approaches
Przemyslaw Lenkiewicz, Manuela Pereira, Mário M. Freire, José Fernandes.
This chapter contains a survey of the most popular techniques for medical image segmentation that have been gaining attention of the researchers and medical practitioners since the early 1980s until present time. Those methods are presented in chronological order along with their most important...
Modeling and Simulation of Deep Brain Stimulation in Parkinson’s Disease
T. Heida, R. Moroney, E. Marani.
Deep Brain Stimulation (DBS) is effective in the Parkinsonian state, while it seems to produce rather non-selective stimulation over an unknown volume of tissue. Despite a huge amount of anatomical and physiological data regarding the structure of the basal ganglia (BG) and their connections, the...
High-Performance Image Reconstruction (HPIR) in Three Dimensions
Olivier Bockenbach, Michael Knaup, Sven Steckmann, Marc Kachelrieß.
Commonly used in medical imaging for diagnostic purposes, in luggage scanning, as well as in industrial non-destructive testing applications, Computed Tomography (CT) is an imaging technique that provides cross sections of an object from measurements taken from different angular positions around the...
Compression of Surface Meshes
Frédéric Payan, Marc Antonini.
The modelling of three-dimensional (3D) objects with triangular meshes represents a major interest for medical imagery. Indeed, visualization and handling of 3D representations of biological objects (like organs for instance) are very helpful for clinical diagnosis, telemedicine applications, or...
New Technologies for Advancing Healthcare and Clinical Practices
As technology becomes further engrained in the modern healthcare experience, an understanding of the impact created by the implementation of each new technology as well as the issues surrounding the today's medical experience is never more necessary.New Technologies for Advancing Healthcare and...